December 9, 2023

Rising Cancer Cases Propel Gene Transplant Market Toward Growth and Innovation

The gene transplant market is experiencing significant growth, driven by advances in genome engineering that have paved the way for the treatment of malignant diseases, notably cancer. Gene transplant procedures involve the introduction of foreign genes directly into cancer cells and surrounding tissues, preventing the spread of cancer cells and ultimately eradicating them. This innovative approach to cancer treatment is expected to fuel the expansion of the gene transplant market in the years ahead.

The Global Cancer Burden

The prevalence of cancer worldwide is on the rise, contributing to the increasing adoption of gene transplant therapies. The International Agency for Research on Cancer (IARC) projects that by 2040, there will be approximately 30 million new cancer cases. In 2020, the Global Cancer Observatory recorded 19,292,789 cancer cases, resulting in 9,958,133 fatalities. Various gene transplant techniques, including anti-angiogenic therapy, suicide gene therapy, RNAi strategies, and oncolytic virotherapy, are being employed to treat various forms of cancer such as lung cancer, brain cancer, breast cancer, liver cancer, colorectal cancer, skin cancer, and pancreatic cancer. The growing global cancer burden is expected to drive the demand for gene transplant therapies, bolstering the gene transplant market’s growth.

Challenges and Risks in Gene Transplantation

Despite the promising potential of gene transplant therapies, the procedure is not without challenges and risks. Gene transplant procedures involve the use of vectors, which are virus-like carriers that deliver genetic material to target cells. While these therapies aim to replace diseased genes with healthy ones to halt diseases, they come with inherent risks. These risks include incorrect cell targeting, unintended immune system responses, the possibility of infections, and the formation of tumors. Such complications can damage healthy cells, trigger immune system inflammation, and lead to organ failure, posing significant challenges to the growth of the gene transplant market.

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Regulatory Support and Collaborative Efforts

To enhance the effectiveness and safety of gene therapy procedures, regulatory bodies such as the National Institutes of Health (NIH) and the FDA are actively involved in overseeing clinical trials. Collaborative initiatives like the Bespoke Gene Therapy Consortium (BGTC), initiated by NIH, aim to streamline and optimize gene transplant procedures while exploring standardized approaches to preclinical testing. NIH and private partners have committed $76 million over five years to support BGTC’s mission. Recent FDA approvals of groundbreaking cell-based therapies, such as treatments for multiple myeloma, are also expected to drive the gene transplant market’s growth.

North America: A Stable Growth Market

North America is poised for stable growth in the gene transplant market, driven by favorable infrastructure and regulations. The United States, for example, has established bodies like the Department of Health and Human Services (DHHS) and the Office for Human Research Protections (OHRP) to monitor clinical trials related to gene transplant. Additionally, the Centers for Disease Control and Prevention (CDC) projects a 49% increase in cancer cases among adults in the United States by 2050. Strategic collaborations between companies, such as the $2.7 billion partnership between Sangamo Therapeutics and Biogen, focusing on gene transplant candidates for Parkinson’s and Alzheimer’s disease, are expected to further stimulate market growth.

Competitive Landscape

Key players in the gene transplant market include Novartis, Gilead Sciences, Biogen, Amgen, AnGes Inc., and Bluebird Bio.

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This press release first seen on Brilad