December 9, 2023

Albumin Market: Addressing Shortages and Rationing in IVIG

The global albumin market is experiencing remarkable growth, driven by its versatile range of applications and increasing demand for plasma-derived medicines. Human serum albumin, a crucial protein found abundantly in blood, serves as a vital tool in various medical treatments and non-therapeutic applications. Here are the key highlights shaping the growth prospects of the albumin market:

Diverse Application Areas Fueling Growth

Albumin’s remarkable versatility makes it a valuable resource across multiple fields, including:

  1. Medical Treatments: Albumin plays a pivotal role in therapies for liver diseases, cardiopulmonary bypass, hemodialysis, trauma resuscitation, burns, hypovolemia, surgical blood loss, and acute respiratory distress syndrome.
  2. Vaccine Ingredient: It is used as a key ingredient in vaccine formulations.
  3. Medical Devices: Albumin serves as a coating for medical devices and equipment.
  4. Surgical Sealant: It is employed as a sealant in surgical procedures.

Plasma-Derived Medicines Drive Growth

The global plasma fractionation market, valued at over US$25 billion, is witnessing robust growth, with albumin emerging as the second-largest segment of plasma-derived medicinal products. Accounting for approximately 15% of global plasma-derived product revenue, albumin’s demand continues to rise. Advances in blood separation processes, coupled with specialized plasma-related products, are expected to further propel the plasma protein market and subsequently the albumin market.

COVID-19 Impact on Albumin Demand

The COVID-19 pandemic has added strain to the already complex demand-supply landscape for albumin. Reduced donor availability due to infections or fear of exposure to COVID-19 in collection centers has disrupted the global plasma supply. Paradoxically, the pandemic has increased the need for plasma, exacerbating an already stressed system.

Human Serum Albumin Dominates; Recombinant Albumin Rising

Among different types of serum albumin, human serum albumin remains dominant in the global market. Its use in non-therapeutic applications, such as an excipient, has garnered significant interest from biopharmaceutical companies, research institutes, and academia.

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Recombinant albumin, manufactured using advanced techniques in yeast and bacteria strains, is poised for robust growth. The industry is shifting from animal and human-derived albumin to chemically-defined recombinant albumin due to its numerous advantages, including high purity, supply certainty, and absence of known or unknown human pathogens.

Market Consolidation Through M&A

The albumin market is highly fragmented, with the top three manufacturers—CSL Limited, Grifols S.A., and Takeda Pharmaceutical Company Limited—capturing over 50% of the market share. These industry leaders are strengthening their positions through strategic mergers and acquisitions involving Chinese suppliers. Notable transactions include CSL Limited’s acquisition of Wuhan Zhong Yuan Rui De Biologics (Ruide) in China and Grifols’ acquisition of Green Cross’ fractionation plant in Canada and 11 plasma centers in the US.

Key Players

Some of the key players in the global albumin market include Biotest AG, Novozymes, Kedrion S.P.A., Merck KGgA, Seracare Life Sciences, Hualan Biologics, and Shanghai Raas.

The global albumin market is on a trajectory of remarkable growth, driven by its expanding applications and the increasing demand for plasma-derived medicines. As it continues to play a critical role in various medical treatments and non-therapeutic applications, the albumin market is expected to maintain its promising pace of development.

Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2023-2030 – By Product, Technology, Grade, Application, End-user, Region: (North America, Europe, Asia Pacific, Latin America and Middle East and Africa)

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This press release first seen on Brilad